Magnetic Induction Heating Enables On-Demand Drug Release via Diels-Alder Polymeric Nanocarriers.

ABSTRACT: As a stimulus-responsive drug release system, we developed Diels-Alder (DA) induction-activated magnetic nanoparticles (DiMaN). Functionalization of polymer-coated magnetic nanoparticles (mNPs) with drugs via thermoreversible DA coupling enabled release through retro-Diels-Alder (rDA) cleavage upon heating. The (pDMAm-co-pFMA)-b-pAAc polymer supported mNP formation and drug binding. DA coupling with maleimide-functionalized drugs was verified by ¹H NMR, showing distinct exo (3.23 ppm) and endo (3.48 ppm) signals after 72 h at 37 °C. Approximately 70% release was observed within 15 min at 80 °C, while the complex maintained stability at 40 °C. The superparamagnetic mNPs generated localized heating under an alternating current magnetic field (192 kHz, 480 A), raising

SUBMITTER: Fujisawa N 

PROVIDER: S-EPMC12606646 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature