YY2 Serves as a Novel Prognostic Biomarker Correlated with Immune Microenvironment and Glycolysis in Esophageal Carcinoma.

ABSTRACT:

Background

Yin Yang 2 (YY2) plays a pivotal role in various tumorigenic processes; however, its specific involvement in esophageal carcinoma (ESCA) remains elusive. This study aims to investigate the expression and potential functional significance of YY2 in ESCA.

Methods

The expression and functions of YY2 in ESCA were analyzed using a broad range of bioinformatics databases and tools, including TCGA, TIMER, TISIDB, QUANTISEQ, cBioPortal, DNMIVD, LinkedOmics, DAVID, GSEA, GEPIA2, LASSO, miRWalk, miRDB, and TargetScan. Furthermore, RT-qPCR, immunohistochemical staining, western blot, CCK8 assay, and wound healing assay were employed to validate the involvement of YY2 in ESCA pathogenesis.

Results

Bioinformatics analyses revealed that the YY2 gene is upregulated in ESC

SUBMITTER: Gou H 

PROVIDER: S-EPMC12606659 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature