Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets.

ABSTRACT: This case report describes a 71-year-old man who presented with hemoptysis, chest pain and shortness of breath. Computed tomography-guided biopsy and immunohistochemical analysis revealed positivity for markers CD34, CD31 and vimentin, confirming the diagnosis of primary pulmonary vascular sarcoma. Genetic testing revealed actionable mutations in CD274 (programmed cell death ligand 1), kinase insert domain receptor, KIT and platelet-derived growth factor receptor α, which may provide targeted treatment options. Unfortunately, the patient's condition rapidly worsened, and he died before therapy was initiated. This case emphasizes the difficulties in diagnosing pulmonary angiosarcoma and highlights potential molecular targets for therapy. Swift disease progression emphas

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12606719 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature