Astragalin Attenuates Bone Destruction and the Progression of Bone Metastasis in Breast Cancer.

ABSTRACT: Background: Bone metastasis of breast cancer (BC) is a key reason for poor prognosis. Recently, natural ingredients derived from plants have been found to exert a broad anti-tumor effect and are considered to be promising candidates for adjuvant therapy. Astragalin (AS) was found to inhibit the progression of several types of tumors; however, the role of AS in regulating the bone metastasis of BC is still unclear. Methods: The effects of AS on the progression of bone metastasis of BC were detected in vivo through safranin O and fast green staining, in vivo living imaging and microCT. The BrdU assay and Annexin V-PI analysis were used to detect the effects of AS on the growth of BC cells. Furthermore, TRAP staining was performed to examine the formation of osteoclasts regulate

SUBMITTER: Yang S 

PROVIDER: S-EPMC12606754 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature