Association between choroid plexus volume and cognitive function in older-age bipolar disorder.

ABSTRACT:

Background

Mounting evidence support that the choroid plexus (CP) plays an important role in aging, cognition and pathogenesis of bipolar disorder (BD). However, the relationship between CP and cognitive dysfunction in older-age bipolar disorder (OABD) has not been investigated.

Methods

A total of 132 OABD patients and 130 healthy controls (HCs) from the UK Biobank were included in our analysis. Between-group differences in CP volume (CPV), gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid volume (CSV) and total brain volume (TBV) were examined. Correlation analysis was performed to explore the relationship between all volumetric measures and composite cognitive function score. By using k-means clustering algorithm, we further identified different cogn

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12606805 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature