-A novel peptide SMIM45-107aa promotes HCC progression via MTDH pathways and its anticancer peptide derivative.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies, and the treatment options are limited. Growing evidence shows that long non-coding RNAs (LncRNAs) encode peptides, suggesting that lncRNAs-derived peptides may play a role in HCC progression and explore their potential as therapeutic targets.

Methods

We used RNA-sequencing and bioinformatics analysis to identify a 107-amino acid peptide, SMIM45-107aa, encoded by LINC00634. The expression levels and prognostic significance of SMIM45-107aa in HCC tissues were assessed by immunohistochemistry (IHC) and Kaplan-Meier. Wound-healing and cell colony formation evaluate the effects of SMIM45-107aa on cell migration and proliferation. A mouse xenograft model was used to examine the tumor formation. In

SUBMITTER: An Y 

PROVIDER: S-EPMC12606820 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature