Advanced nitric oxide-activated calcium overload and zinc ion-amplified oxidative imbalance in ferroptosis/apoptosis.

ABSTRACT:

Background

Ferroptosis, a programmed cell death driven by lipid peroxidation, relies on an oxidative imbalance. However, tumor cells counteract the effects of oxidative imbalance through adaptive defense mechanisms and metabolic reprogramming, thereby limiting the therapeutic efficacy of ferroptosis.

Results

An antitumor strategy was designed to synergistically induce ferroptosis and apoptosis by targeting the release of nitric oxide (NO) and zinc ions (Zn²⁺), effectively disrupting the redox homeostasis and antioxidant capacity of tumor cells. ZIF-8 degradation in tumor cells triggers Zn²⁺-mediated mitochondrial electron transport chain inhibition and nicotinamide adenine dinucleotide phosphate oxidase 1 activation, significantly increasing endogenous

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12606892 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature