Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) is highly expressed in the hypothalamus where it exerts regulatory functions over neurogenesis, reproduction, energy balance, and metabolism. Analyzing a hypothalamic single-nucleus transcriptomic, we identified Fezf1 ventromedial hypothalamic (VMH) neurons as an important source of BDNF. During development, Fezf1 neurons are involved in the organization of the olfactory bulb, and mutations on this gene are responsible for Kallmann syndrome; however, in adult life, little is known about the functions of Fezf1 neurons.

Methods

In this study, we aimed at providing advance in the characterization of Fezf1 neurons and exploring the role of Fezf1-BDNF in the regulation of the metabolic phenotype of mice. Hypothalamic immunofluor

SUBMITTER: Cabral-da-Silva D 

PROVIDER: S-EPMC12606896 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature