The biological scaling of Alzheimer's disease neuropathological changes across primate species.

ABSTRACT:

Background

Studying the spontaneous emergence of biological anomalies within the animal kingdom can provide insights into the causes of diseases. It is often assumed that Alzheimer's Disease (AD), like other neurodegenerative diseases, is specific to humans. However, the age-related occurrence of AD neuropathological changes (ADNC) in non-human primates (NHPs) and their comparison with humans has not been formally studied. Moreover, a conceptual framework for interpreting the spontaneous occurrence of ADNC in NHPs has yet to be established.

Methods

We conducted a systematic review of the available data describing spontaneous ADNC in various NHP species. To study the biological scaling of ADNC, we used logistic regression models to compare NHP and human findings, based on bot

SUBMITTER: Toussaint C 

PROVIDER: S-EPMC12606912 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature