Effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy: a study protocol of double-center, double-blind, randomized controlled trial.

ABSTRACT:

Introduction

Esophageal cancer is the eighth most prevalent malignant tumor in the world and has the sixth highest mortality rate. Postoperative pulmonary complications (PPCs) are one of the most common complications of minimally invasive esophagectomy (MIE). The non-local anesthetic effects of lidocaine have been widely reported, but only a few studies have focused on its effects on lung protection in MIE. This study is designed to test the hypothesis that intraoperative intravenous lidocaine infusion can reduce the incidence of PPCs in patients undergoing MIE.

Methods and analysis

In this double-center, randomized, double-blind, placebo-controlled superiority trial, 770 participants from three centers will be randomly assigned to two groups, namely the lidocaine group and

SUBMITTER: Wang F 

PROVIDER: S-EPMC12606923 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature