High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aimed to evaluate the prevalence and risk factors of sarcopenia in patients with knee osteoarthritis (KOA) through a systematic review and meta-analysis.

Methods

A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Scopus, China National Knowledge Infrastructure, and WanFang databases for studies published between January 2000 and June 2025. Eligible studies were screened according to predefined inclusion and exclusion criteria. Data were extracted, study quality was assessed, and meta-analyses were performed using Stata 17.0.

Results

A total of 35 studies involving 13,528 KOA patients were included, of whom 3597 were diagnosed with sarcopenia. The pooled prevalence of sarcopenia and sarcopenic obesity was 25.07% (95%

SUBMITTER: Chen TX 

PROVIDER: S-EPMC12606924 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature