A six-year longitudinal study identifies a statin-independent association between low LDL-cholesterol and risk of type 2 diabetes.

ABSTRACT:

Background

Statin therapy has been associated with increased risk of type 2 diabetes (T2D). We investigated the relationship between Low-Density Lipoprotein Cholesterol (LDL-C) plasma concentrations and incident T2D and evaluated the modifying effect of statin therapy in a large population-based cohort.

Methods

Individuals free of T2D and cardiovascular disease at baseline were followed longitudinally for the development of new-onset T2D. Cox proportional hazards models were applied to evaluate the associations of LDL-C levels and statin therapy with T2D risk.

Results

From a population of 202,545 individuals, we selected 13,674 participants free of T2D and cardiovascular disease (of whom 52% were on statins), who were followed for a median of 71.6 months (IQR 34.5-149

SUBMITTER: Lembo M 

PROVIDER: S-EPMC12606927 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature