The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study.

ABSTRACT:

Background

Protein restriction increases lifespan, however, the specific amino acids affecting lifespan are unclear. Tyrosine and its precursor, phenylalanine, may influence lifespan through their response to low-protein diet, with possible sex disparity.

Methods

We applied cohort study design and Mendelian randomization (MR) analysis. Specifically, we examined the overall and sex-specific relationships between circulating phenylalanine and tyrosine and all-cause mortality in the UK Biobank using Cox regression. To test causality, in two-sample MR analysis, we used genetic variants associated with phenylalanine and tyrosine in UK Biobank with genome-wide significance and uncorrelated (r² < 0.001) with each other, and applied them to large genome-wide association s

SUBMITTER: Zhao JV 

PROVIDER: S-EPMC12606968 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature