Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.

ABSTRACT: Synucleinopathies are age-dependent neurodegenerative diseases characterized by alpha-synuclein accumulation with distinct vulnerabilities across brain regions. Understanding early disease stages is essential to uncover initial molecular changes that might enable earlier diagnosis and causal therapy. In this study, we profiled longitudinal and brain region-resolved gene expression changes in a rat model of synucleinopathies overexpressing human SNCA. Transcriptomic analyses were performed on gene and transcript level of striatal, frontocortical, and cerebellar tissue in 5- and 12-month-old transgenic (BAC SNCA) and wild type rats revealing that SNCA overexpression leads to age-dependent transcriptomic changes that largely occur region-specific. In frontal cortex, dysregulatio

SUBMITTER: Hoof V 

PROVIDER: S-EPMC12606970 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature