Clinical-genetic profiles and risk prediction model in childhood restrictive cardiomyopathy: a national cohort study of China.

ABSTRACT:

Background

Understanding restrictive cardiomyopathy (RCM) in children is limited, and currently, no prognostic model is available for assessing risk stratification in pediatric RCM. The authors elaborated on the clinical and genetic characteristics of pediatric RCM and developed a prediction model to assess the 1-year risk of major adverse cardiovascular events (MACE), aiding in determining the optimal timing for heart transplantation (HTx).

Methods

This multicenter retrospective cohort study collected data on children with RCM from 14 centers in China, with patient enrollment from January 1, 2013, to December 31, 2022, and follow-up concluding on August 1, 2023. It analyzed clinical and genetic characteristics and followed patients longitudinally for the development of MACE

SUBMITTER: Chen H 

PROVIDER: S-EPMC12606984 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature