A retrospective analysis of phase I and phase I/II investigator-initiated clinical trials conducted by the Swiss Group for Clinical Cancer Research (SAKK).

ABSTRACT:

Background

Phase I trials represent the initial step in the clinical evaluation of a new drug or new drug combination. The main characteristics and designs of phase I trials have changed throughout the years to better support the development of drugs with different specificities compared with traditional chemotherapy.

Patients and methods

We reviewed early-stage investigator-initiated clinical trials conducted by the Swiss Group for Clinical Cancer Research (SAKK) within the last 20 years at a patient and clinical trial level. For efficacy analysis, patients were grouped into advanced/metastatic solid tumors, nonadvanced solid tumors, and lymphoma.

Results

The study included 295 patients from 20 clinical trials. Systemic drug combinations were the most common treatmen

SUBMITTER: Koster KL 

PROVIDER: S-EPMC12606996 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature