Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited molecular characterization due to reliance on radiological diagnosis. This study aims to characterize the genomic landscape of advanced HCC and assess the prognostic and predictive roles of genetic alterations (GAs).

Patients and methods

This study used a de-identified nationwide (USA-based) HCC clinico-genomic database to retrospectively analyze patients with advanced HCC who received systemic therapies and underwent comprehensive genomic profiling via tissue or liquid biopsy. GAs were identified using Foundation Medicine, Inc.'s next-generation sequencing tests. Time to progression (TTP) was assessed using Kaplan-Meier analysis and Cox proportional hazards models.

Resu

SUBMITTER: Salani F 

PROVIDER: S-EPMC12607002 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature