Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an effective treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). However, optimizing lead placement and stimulation parameters remains a challenge. DBS evoked potentials (EPs) recorded with electroencephalography (EEG) during surgical lead placement could serve as intraoperative biomarkers for target engagement and clinical efficacy.

Methods

We obtained intraoperative EEG recordings on the forehead from 10 patients (2 nonresponders) undergoing ALIC DBS surgery for OCD. Monopolar stimulation at 2 Hz was delivered through all electrode contacts, and EEG EPs were analyzed in relation to stimulation contact, white matter connectivity to the prefrontal cortica

SUBMITTER: Van Bogaert T 

PROVIDER: S-EPMC12607010 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature