One-Year Myopia Control Efficacy of a New Defocus Spectacle Lens: A Randomized Clinical Trial.

ABSTRACT:

Purpose

To evaluate the efficacy and safety of the new defocus spectacle lens in preventing myopia progression compared with the conventional single-vision spectacle lens (SVL).

Design

A randomized, open-label, controlled clinical trial.

Subjects

Children aged 6 to 14 years with a cycloplegic spherical equivalent refraction (SER) of -1.00 to -3.50 diopters (D) in both eyes were enrolled.

Methods

Eligible participants were randomly assigned in a 1:1 ratio to receive either the novel defocus spectacle lens (MYOGEN) or the SVL. Data from the right eyes at the 12-month follow-up were used for the current analysis.

Main outcome measures

The primary outcome was the 1-year change in SER from baseline to 12 months. Secondary outcomes included changes in axial le

SUBMITTER: Han X 

PROVIDER: S-EPMC12607012 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature