A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.

ABSTRACT: Effective repair of spinal dural defects is essential to prevent cerebrospinal fluid (CSF) leakage and preserve neurological function. However, conventional suture-based methods and clinical bioadhesives often face challenges such as technical complexity, inadequate sealing, and fibrotic adhesion. Here, we present a dynamically adaptive Janus hydrogel patch (DHP) that enables rapid, suture-free sealing while minimizing postoperative adhesion. DHP is fabricated through the self-assembly of viscoelastic polymers into a phase-separated architecture featuring hydrophilic-hydrophobic microdomains, which enables stable and reversible wet adhesion via synergistic interfacial water removal and conformal surface adaptation. The hydrogel exhibits tissue-compliant mechanics, self-healing capability,

SUBMITTER: Su X 

PROVIDER: S-EPMC12607057 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature