Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.

ABSTRACT: The development of interventional therapies that can effectively alleviate joint wear and promote cartilage regeneration is a major challenge in the clinical management of osteoarthritis (OA). This study aimed to develop an injectable microgel system with synergistic therapeutic functions. For decades, plant-derived exosome-like nanovesicles (PELNs) have gradually become an emerging direction in the research and development of disease intervention methods. To determine the most suitable PELNs in the treatment of OA, this study conducted mendelian randomization (MR) analysis to reveal the protective effect of watercress intake on OA progression from a wide range of dietary plants. The watercress-derived exosomes-like nanovesicles (WELNs) were isolated, and WELNs-CAP was modified with chondr

SUBMITTER: Yan R 

PROVIDER: S-EPMC12607081 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature