BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: An <i>in vitro</i> and <i>in vivo</i> assessment.

ABSTRACT: The repeated dressing changes, especially for infected wounds and those with high exudate, and applying drugs daily, are huge demands in wound management. Sustained and regulated medication release of BCS II/IV antibiotics improves chronic wound therapy. The poor solubility and absorption of BCS-class medicines makes it challenging at target site. This work seeks to build 3D nano scaffolds for administering ciprofloxacin, a BCS II/IV class medication, using biocompatible sulphonated polyether ether ketone mat produced by electrospinning, which is flexible. We demonstrated a reliable method to prevent burst drug release and maintain it for three weeks, with good biocompatibility, minimal cytotoxicity, and excellent tensile strength characterizing sulphonated polyether ether ketone. Nanofibe

SUBMITTER: Padinjarathil H 

PROVIDER: S-EPMC12607090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature