Prognostic significance of the CALLY index for cancer risk and survival: evidence from NHANES 2001-2018.

ABSTRACT:

Background

The C-reactive protein-albumin-lymphocyte (CALLY) index is an immune-nutritional biomarker associated with cancer prognosis. Its relevance to cancer incidence and long-term survival in the general population has not been well established.

Methods

We analyzed NHANES 2001-2018 data from 36,904 participants, including 3,218 cancer patients. Logistic regression assessed cancer risk, and Cox proportional hazards models evaluated all-cause, cancer-specific, and cardiovascular mortality among cancer survivors. Restricted cubic splines (RCS) examined nonlinear associations, and subgroup analyses were stratified by age and sex.

Results

Cancer patients showed lower CALLY index values. Compared with the lowest quartile, the highest quartile was associated with a reduc

SUBMITTER: Wen Y 

PROVIDER: S-EPMC12607156 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature