Association between sodium-chloride difference at ICU admission and 30-day mortality: a retrospective cohort study of critically ill adults.

ABSTRACT:

Background

The difference between serum sodium and chloride concentrations (SCD) is a simple parameter reflecting the interplay between major extracellular electrolytes. We investigated whether SCD assessed upon intensive care unit (ICU) admission holds predictive value for short-term outcomes in critically ill adults.

Methods

We retrospectively analyzed 1,726 consecutive patients admitted to a mixed (medical-surgical) ICU (median age 67 years; 70.7% male). The relationship between admission SCD and 30-day mortality was first assessed using restricted cubic spline (RCS) regression to explore non-linearity. To define potential thresholds, cut-off values were evaluated using ROC analysis with the Youden index. Cox proportional hazards models were then applied. Internal validat

SUBMITTER: Swistek R 

PROVIDER: S-EPMC12607177 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature