Interactions between lipid droplets and mitochondria in metabolic diseases.

ABSTRACT: Metabolic diseases, a major challenge in global public health, are commonly characterized by insulin resistance, lipid metabolism disorders, and mitochondrial dysfunction, and their pathological processes are often accompanied by the abnormal accumulation of lipids in metabolically active tissues such as the liver, heart, and skeletal muscle. Recently, lipid droplets and mitochondria have been shown to interact with each other through membrane contact sites and play a central role in maintaining cellular metabolic homeostasis. The unique monolayer phospholipid membrane structure and formation process of lipid droplets, along with the double-membrane structure and diverse functions of mitochondria, together form the basis for their interaction. There are two modes of interaction, namely dyn

SUBMITTER: Wang G 

PROVIDER: S-EPMC12607196 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature