Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis.

ABSTRACT:

Background

Peripheral nerve injury (PNI) is a major clinical challenge with limited effective therapeutic options. Our prior work has demonstrated that SJMHE1, a peptide derived from Schistosoma japonicum, promotes peripheral nerve regeneration by regulating M2 macrophages; however, its downstream molecular mechanisms remain unclear. Migrasomes are newly identified migration-dependent extracellular vesicles that mediate intercellular communication, and are abundantly produced by highly migratory macrophages. The present study investigates whether SJMHE1 promotes peripheral nerve regeneration through macrophage-derived migrasomes, with a focus on the role of these migrasomes in macrophage-Schwann cell crosstalk.

Methods

The formation of migrasomes was observed using an in viv

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12607197 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature