Bone microarchitecture assessed by High-resolution peripheral quantitative computed tomography in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study.

ABSTRACT: The mechanism for bone fragility in type 1 diabetes (T1D) is unclear. We performed advanced analyses on HR-pQCT images from participants with T1D (n = 183, 59.5 ± 7.0 yr, 50.8% female, T1D duration 38.0 ± 4.8 yr) enrolled in the Epidemiology of Diabetes Interventions and Complications (EDIC) study and a demographically similar group of nondiabetic controls (n = 94, 60.5 ± 8.2 yr, 65.6% female). Between participants and controls, we compared trabecular morphology by individual trabecula segmentation (ITS) analysis (decomposes trabeculae into plate-like and rod-like structures), and assessed cortical topology by cortical pore skeletonization (CPS) analysis (classifies pores as slab-like or tube-like and analyzes connectivity) and by cortical laminar analysis (CLA) (quantifies d

SUBMITTER: Rubin M 

PROVIDER: S-EPMC12607258 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature