Metabolism, pharmacokinetics, and bioavailability of cannabigerol in horses following intravenous and oral administration with micellar and oil formulations.

ABSTRACT:

Introduction

Cannabigerol (CBG) is a non-psychoactive cannabinoid with growing interest in veterinary medicine; however, its pharmacokinetic profile in horses remains unknown. Understanding its absorption, distribution, metabolism, and elimination is essential to optimizing dosing strategies and evaluating its potential for clinical use in equine patients.

Methods

A prospective crossover study was conducted in eight healthy adult horses to assess the in vivo metabolism and the pharmacokinetics after intravenous (IV) administration at 1 mg/kg and oral administrations at 10 mg/kg with two formulations (micellar and oil). Plasma concentrations of CBG and its main metabolite, CBG-glucuronide (CBG-G), were analyzed by LC-MSMS and modeled using a non-linear mixed effects mo

SUBMITTER: Serrano-Rodriguez JM 

PROVIDER: S-EPMC12607281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature