Astrocyte Transcriptomics in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream.

ABSTRACT: The glial tube is a longitudinal structure predominantly composed of densely bundled, aligned astrocytes that projects from the subventricular zone (SVZ) to the olfactory bulb. Neural precursor cells (NPCs) generated in the SVZ migrate through this glial tube-referred to as the rostral migratory stream (RMS)-to replace olfactory bulb interneurons in the mammalian brain. RMS astrocytes have distinct morphological and functional characteristics. These characteristics facilitate the unique purpose of the RMS as an endogenous living scaffold directing NPC migration and maturation. However, the transcriptomic factors underlying these unique structure-function attributes versus standard stellate astrocytes have not been examined. We previously developed biofabrication techniques to create the fi

SUBMITTER: Grovola MR 

PROVIDER: S-EPMC12607521 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature