Type 1 conventional dendritic cells regulate innate immunity during fungal pneumonia.

ABSTRACT: Aspergillus fumigatus is a ubiquitous mold that is the primary etiological agent of invasive pulmonary aspergillosis (IPA), a severe lung infection in immunocompromised patients with extreme mortality. Innate immunity is critical for controlling the severity of IPA. Regarding dendritic cells (DCs), studies have shown protective roles for monocyte-derived DCs and plasmacytoid DCs during IPA. Here, we examined the role of type 1 conventional dendritic cells (cDC1s) during A. fumigatus lung infection. We first show that global depletion of DCs resulted in impaired lung clearance of A. fumigatus, indicating a protective role for DCs, as expected. Unexpectedly, however, mice lacking cDC1s (Batf3-/-) cleared A. fumigatus more efficiently than wild-type C57BL/6

SUBMITTER: Dhruva PM 

PROVIDER: S-EPMC12607573 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature