Anticancer Activity of Triterpene Glycosides Cucumarioside A₀-1 and Djakonovioside A Against MDA-MB-231 as A_2B Adenosine Receptor Antagonists.

ABSTRACT: Breast cancer is the most prevalent cancer in women worldwide and presents a major therapeutic challenge, particularly triple-negative breast cancer (TNBC), a subtype characterized by an aggressive clinical course but heightened sensitivity to chemotherapy. Natural products, such as triterpene glycosides derived from sea cucumbers, have emerged as promising candidates with high anticancer potential against TNBC. This study investigated the pathways of anticancer action of cucumarioside A₀-1 (Cuc A₀-1) and djakonovioside A (Dj A), isolated from the sea cucumber Cucumaria djakonovi, triggered and regulated in MDA-MB-231 cells (triple-negative breast cancer cell line). We employed functional assays (cAMP level, Ca²⁺ influx, control of cell proliferation

SUBMITTER: Zelepuga EA 

PROVIDER: S-EPMC12607671 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature