Spatial Modularity of Innate Immune Networks Across Bactrian Camel Tissues.

ABSTRACT: The Bactrian camel exemplifies mammalian adaptation to deserts, but the spatial organization of its innate immune system remains uncharacterized. This study integrated transcriptomes from 110 samples across 11 major tissues and organs to resolve tissue-specific gene expression and innate immune modularity. Through differential expression analysis, Tau specificity index (τ > 0.8), and machine learning validation (Random Forest F1-score = 0.86 ± 0.11), we identified 4242 high-confidence tissue-specific genes (e.g., LIPE/PLIN1 in adipose). Weighted gene co-expression network analysis (WGCNA) of 1522 innate immune genes revealed 11 co-expression modules, with six exhibiting significant tissue associations (FDR < 0.01): liver-specific (r = 0.96), spleen-adipose-enriched (r = 0.88)

SUBMITTER: Guo L 

PROVIDER: S-EPMC12607672 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature