PPE51 modulates membrane integrity in <i>Mycobacterium marinum</i>.

ABSTRACT: PPE proteins, which are exclusive to mycobacteria, are substrates of type VII secretion systems, also unique to this genus. Their function has been an enigma for a long time, but has recently received attention for their association with nutrient uptake across the mycobacterial outer membrane. One of these nutrient transporters is PPE51, involved in glycerol and glucose uptake in Mycobacterium tuberculosis. We investigated the role of PPE51 proteins in nutrient uptake and membrane integrity using the model organism Mycobacterium marinum, whose genome encodes four paralogs. We created single, double, and triple mutants of ppe51 and noted that the presence of the final ppe51 gene was essential. To determine if PPE51's function is conserved in M. marinum, we

SUBMITTER: Charitou V 

PROVIDER: S-EPMC12607722 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature