Detection of Genes Associated with Polymyxin and Antimicrobial Peptide Resistance in Isolates of <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pseudomonas aeruginosa causes ocular and other infections and quickly acquires antimicrobial resistance. Polymyxin B and colistin are last-line agents against resistant P. aeruginosa, yet even resistance to these is increasing. Antimicrobial peptides (AMPs) are also being developed as new antibiotics, but resistant mechanisms to polymyxins might also cause resistance to these AMPs. This study evaluated whether isolates with differing polymyxin resistances also showed elevated minimum inhibitory concentrations (MICs) to the human cathelicidin LL-37 and a synthetic AMP, Mel4. Forty isolates of P. aeruginosa, mostly collected in India and Australia, were assessed for minimum inhibitory concentrations (MICs) by broth microdilution in cation-adjusted Mueller-Hinton broth. W

SUBMITTER: Damtie MA 

PROVIDER: S-EPMC12607733 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature