Upstaging of Patients Diagnosed with Favorable Intermediate-Risk Prostate Cancer-Is Active Surveillance Really a Suitable Approach for All These Patients?

ABSTRACT:

Background & objectives

Current guidelines recognize a subgroup of favorable intermediate-risk (FIR) ISUP grade group (GG) 2 prostate cancer (PCa) that may be eligible for active surveillance (AS). However, upgrading and upstaging to more aggressive disease are frequently observed. We aimed to identify risk factors for adverse pathology in this cohort to better define clinical scenarios where AS may need to be reconsidered.

Methods

We retrospectively analyzed 170 patients diagnosed with ISUP GG2 PCa by multiparametric MRI (mpMRI)/TRUS fusion biopsy, all treated with radical prostatectomy (RP). Patients with FIR disease were evaluated for upstaging to ≥pT3 or upgrading to ISUP GG of ≥3 at RP. Multivariable logistic regression identified predictors of adverse pathology. Key Fi

SUBMITTER: Handke AE 

PROVIDER: S-EPMC12607737 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature