Polycomb repressive complex 2 regulates sexual development in <i>Neurospora crassa</i>.

ABSTRACT: In most branches of the fungal kingdom, sexual development marks a dramatic shift from simple multicellular hyphae to complex fruiting bodies composed of multiple tissues and cell types. It is essential to tightly regulate development to prevent unnecessary energy investment into building these structures. Polycomb repressive complex 2 (PRC2) is a highly conserved regulator of development in multicellular organisms. In plants, animals, and some fungi, PRC2 tri-methylates histone H3 lysine 27 in promoters and gene bodies to repress gene expression. In Neurospora crassa, H3K27me3-associated genes are poorly conserved and stably repressed in standard lab conditions. Through analysis of publicly available RNA-seq experiments, we found that PRC2-methylated genes are specifically activate

SUBMITTER: Deaven AM 

PROVIDER: S-EPMC12607757 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature