Alpha-toxin-elicited CX₃CL1 release in <i>Staphylococcus aureus</i> pneumonia impairs bactericidal function of human monocytes.

ABSTRACT: Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin. In this study, we found that patients with S. aureus respiratory tract infections had elevated CX₃CL1 levels in airway fluid and plasma. Using human-organotypic lung models, we observed that stimulation of lung epithelium with α-toxin induces an intensified CX₃CL1 expression apically in the epithelium as well as the release of CX₃CL1. Blocking α-toxin or ADAM10 activity in organotypic lung using an α-toxin-blocking antibody or a specific ADAM10 inhibitor confirmed their role in modulating CX₃CL1 cleavage and relea

SUBMITTER: Mairpady Shambat S 

PROVIDER: S-EPMC12607776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature