A cyclic di-GMP phosphodiesterase in the VSP-2 island of <i>Vibrio cholerae</i> is regulated by zinc and quorum sensing.

ABSTRACT: The second messenger cyclic di-GMP (cdG) is indispensable for the regulation of biofilm formation, motility, and a variety of other important bacterial behaviors in the majority of bacteria. The human pathogen Vibrio cholerae has a diverse repertoire of diguanylate cyclase and phosphodiesterase (PDE) enzymes that control the intracellular cdG concentration depending on local environmental cues and its physiological state. Determining the transcriptional regulation of these enzymes and the respective environmental signals that control their activity is important to understand how and when V. cholerae switches between motile and sessile lifestyles in different environments. In some strains of the current V. cholerae seventh pandemic El Tor biotype, the horizontally acqui

SUBMITTER: Rangarajan AA 

PROVIDER: S-EPMC12607878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature