Persistent multispecies dissemination of <i>armA</i>-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.

ABSTRACT: Aminoglycoside resistance mediated by 16S rRNA methyltransferases poses a growing threat in both human and veterinary medicine. Here, we conducted a retrospective genomic study of Enterobacterales isolates (n = 789) collected from clinical samples at a veterinary teaching hospital in Spain between 2011 and 2020. We identified four high-level aminoglycoside-resistant ST171 Enterobacter hormaechei subsp. xiangfangensis isolates carrying the armA gene, all from horses. Using Illumina and Nanopore sequencing, we determined that armA was located on a 70 kb IncR plasmid, also carrying other resistance genes such as msr(E), mph(E), bla_DHA-1, and qnrB4, embedded within a Tn1548-like element. Genomic comparisons indica

SUBMITTER: Serna C 

PROVIDER: S-EPMC12607884 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature