An in-house <i>Kingella kingae</i> PCR in a large pediatric cohort: impact on diagnosis, antimicrobial stewardship, and clinical outcomes.

ABSTRACT: Kingella kingae is a bacterial pathogen associated with bone and joint infections and a major pathogen in pediatric populations, particularly in those ≤5 years of age. Molecular detection methods have demonstrated significant increases in sensitivity compared to culture, allowing rapid and accurate identification. The objective of this study was to characterize the performance of an in-house K. kingae PCR (KKIN PCR) and determine its impact on antimicrobial utilization and clinical management in a pediatric population. Laboratory records from 1 September 2014 to 31 January 2024 were reviewed to identify subjects ≤18 years old who had KKIN PCR testing performed at Nationwide Children's Hospital. Demographics, symptoms, radiologic and laboratory findings, hospitalization status

SUBMITTER: Oyeniran SJ 

PROVIDER: S-EPMC12607887 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature