Developing genome typing strategies for the emerging zoonotic pathogen <i>Streptococcus parasuis</i>.

ABSTRACT: The reported human infections with the emerging zoonotic pathogen Streptococcus parasuis are steadily rising. Rapid and standardized genotyping tools specific to S. parasuis are critically needed for epidemiological surveillance and identification of strains with zoonotic potential. This study developed a whole-genome sequence (WGS)-based typing strategy, encompassing average nucleotide identity, a minimum core genome (MCG) typing scheme, and a multilocus sequence typing (MLST) scheme using 255 S. parasuis genomes isolated from eight countries between the 1980s and 2024. The S. parasuis population was categorized into 12 MCG clusters based on 72,172 SNPs in non-recombining regions distributed across an MCG comprising 607 genes, forming two distinct lineag

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12607890 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature