Recurring acquisition of carbapenemase genes and global emergence of <i>Pseudomonas aeruginosa</i> ST-1047, a lineage shaped by geopolitical conflicts.

ABSTRACT: Pseudomonas aeruginosa sequence type (ST)-1047 is emerging globally as a carbapenemase-rich lineage, yet its evolutionary history and population structure are not known. Here, we performed a comprehensive genomic and epidemiological investigation of 141 ST-1047 isolates from 15 countries, integrating short- and long-read sequencing data with Bayesian phylogenetics and mobile genetic element analyses. Two clonal subpopulations were identified. Subclone 1, defined by bla_VIM-11 carriage and loss of exoU, is proposed to have been imported to the United States following the medical evacuation of wounded service members from Afghanistan in 2005 and later seeded a nosocomial outbreak in Washington state. Subclone 2, carrying bla_IMP-1, is undergoin

SUBMITTER: Luo TL 

PROVIDER: S-EPMC12607901 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature