In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing.

ABSTRACT: The skin acts as a primary barrier against environmental insults and maintains homeostasis. Injury initiates a wound healing cascade of hemostasis, inflammation, proliferation, and remodeling. In chronic wounds, persistent microbial colonization and inflammation disrupt this process, with bacterial virulence factors acting as key drivers. While the microbiome's role in chronic wounds is recognized, the effects of individual virulence factors on acute repair remain unclear. Therefore, this study investigated the differential effects of virulence factors derived from five skin-associated bacterial species on acute wound healing dynamics. In this context, virulence factors from Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Lactobacillus plantar

SUBMITTER: Hammad AS 

PROVIDER: S-EPMC12607956 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature