Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT: Evidence is accumulating that there is a bidirectional relationship between thyroid function and the gut microbiome. We assessed associations of gut microbiome-derived circulating metabolites, choline, trimethylamine N-oxide (TMAO), and betaine with thyroid function status. Among 4771 euthyroid participants of the community-dwelling PREVEND cohort study (thyroid stimulating hormone (TSH), free thyroxine, and free triiodothyronine levels within the reference range; no use of thyroid function altering medication), associations of TSH (higher levels indicating low-normal thyroid function) with choline, TMAO, and betaine (determined by nuclear magnetic resonance spectroscopy) were assessed. Plasma choline varied by TSH category with the highest values observed in the highest TSH quartile (p

SUBMITTER: Post A 

PROVIDER: S-EPMC12608030 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature