Mixed-Layered Glycodendrimer Probe for Imaging Inflammation at Surgical Site Infections.

ABSTRACT: Surgical site infections (SSIs) remain the most common cause for readmission following surgery and are associated with significant medical comorbidities. Distinguishing between inflammation and early infection postsurgery is a critical challenge for clinicians. Intraoperative surgical debridement of infectious tissues relies heavily on the surgeon's experience, risking error due to difficulty in distinguishing infection from inflammation. We evaluated the simultaneous use of two fluorescent probes, maltotriose-indocyanine-green (ICG-DBCO-maltotriose) and a mixed-layered 2-deoxyglucose dendrimer (2DG-D) labeled with cyanine 5 (2DG-D-Cy5), to delineate between SSI and inflammation in vitro in cell-bacteria coculture and in vivo in an early implant SSI model via multiplexed short-wave infrare

SUBMITTER: Dhull A 

PROVIDER: S-EPMC12608046 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature