Age-Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus.

ABSTRACT: Aging represents a major risk for human neurodegenerative disorders, such as dementia and Alzheimer's disease, and is associated with a functional decline in neurons and impaired synaptic plasticity, leading to a gradual decline in memory. Previous research has identified molecular and functional changes associated with aging through transcriptomic studies and neuronal excitability measurements, while the role of chromatin-level regulation in vulnerability to aging-related diseases is not well understood. Moreover, the causal relationship between molecular alterations and aging-associated decline in functions of different cell types remains poorly understood. Here, we systematically characterized gene regulatory networks in a cell type-specific manner in the aging mouse hippocampus, a cent

SUBMITTER: Bilgic M 

PROVIDER: S-EPMC12608092 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature