Cedrol prevents UVB-induced photoaging by restoring mitochondrial function, metabolic homeostasis, and skin barrier integrity in HaCaT cells.

ABSTRACT:

Context

Ultraviolet B (UVB) radiation is a key environmental contributor to skin photoaging, primarily by inducing oxidative stress, mitochondrial dysfunction, metabolic imbalance, and downregulation of tight junction (TJ) proteins. Cedrol, the major component of the essential oil from Cunninghamia lanceolata var. konishii, a tree species endemic to Taiwan, exhibits antioxidant properties. However, its restorative effects against UVB-induced skin damage have not been fully elucidated.

Objective

In this study, HaCaT keratinocytes were used to evaluate the post-treatment effects of cedrol on UVB-induced damage to skin cells.

Materials and methods

HaCaT cells were exposed to UVB irradiation followed by cedrol treatment. Cell viability, intracellular reactiv

SUBMITTER: Xu MR 

PROVIDER: S-EPMC12608100 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature