Discovery of Potential Antileishmanial Compounds Through Phenotypic Screening of an Alkaloid Library.

ABSTRACT: Visceral leishmaniasis caused by Leishmania donovani is one of the major neglected tropical diseases attributable to parasitic protozoa. In the absence of an effective vaccine, chemotherapy remains the only available therapeutic option. However, current treatments rely on a limited number of drugs that are largely obsolete, highly toxic or require intravenous administration, and their extensive use has led to the emergence of drug resistance. Consequently, the discovery of new antileishmanial agents is an urgent priority. In this study, a commercial library of 449 alkaloids in a high-throughput screening format was evaluated against both axenic bone marrow-derived amastigotes and intramacrophagic amastigotes from mice infected with L. donovani IRFP, a strain engineered to emi

SUBMITTER: Soh-Kamdjo C 

PROVIDER: S-EPMC12608155 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature