Efficacy of Bone Marrow-Derived Stem Cells on Non-Ischemic Cardiomyopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT: Background/Objectives: Non-ischemic cardiomyopathy (NICM) refers to myocardial disease characterized by structural and functional impairment without coronary artery disease. Stem cell therapy has emerged as a potential treatment to restore heart function in NICM, but clinical results have been inconsistent. Methods: This meta-analysis comprises five randomized controlled trials with a total of 302 patients, retrieved from PubMed, ScienceDirect, the Cochrane Library, and SAGE Journals. Results: Compared with the control group, stem cell therapy group showed significant improvements in the left ventricular ejection fraction (LVEF) at the 3-month follow-up (MD = 4.55, 95% CI 2.12-6.98, p = 0.0002), a reduction in the left ventricular end-diastolic diameter (LVEDD)

SUBMITTER: Soetisna TW 

PROVIDER: S-EPMC12608168 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature