Advances in Lycopene Production: From Natural Sources to Microbial Synthesis Using <i>Yarrowia lipolytica</i>.

ABSTRACT: Lycopene, a natural carotenoid with antioxidant and health-promoting properties, has attracted attention as a valuable compound for the food, pharmaceutical, and cosmetic industries. Conventional production methods based on plant extraction or chemical synthesis are limited by low yields, high costs, and environmental concerns. In this study, the oleaginous yeast Yarrowia lipolytica was engineered as an alternative microbial cell factory for sustainable lycopene biosynthesis using short-chain fatty acids (SCFAs)-such as acetate, butyrate, and propionate-as inexpensive, renewable carbon sources. Four heterologous genes from Pantoea agglomerans (crtI, crtB, crtE, and idi) were codon-optimized and integrated into the Y. lipolytica genome using

SUBMITTER: Moroz P 

PROVIDER: S-EPMC12608319 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature